Originally Posted by Danke
Molle if you aren't sure of where you want gear or plan to run a few different rigs.
Fixed pouches for light weight/low profile.
If you know what you want and don't think it's going to be changing then fixed is cheaper, lighter and lower profile. If you are not sure how you want to run your loadout and you have money to spare then molle.
I personally knew exactly what I wanted and knew I wasn't changing, so I got an Eagle fixed chest rig and it's served me very well over the years. No regrets here.